It has been proved as a state whereby the immune system is 
activated to react against and attack the body's own tissues and may happen next 
to other diseases such as thyroid disease or pernicious 
anemia. Vitiligo is probably the commonest cause of 
depigmentation and generates a lot of concern due to the fact that it causes 
not only depigmentation but also makes the skin color very uneven and patchy , and hence unsightly.
1) Disfiguring lesions which cause the patient to be embarrassed 
or made fun of and cause psychological problems and difficulties making friends.